Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

The DNA Helix

The DNA Helix

The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

The DNA Helix

The DNA Helix

Nucleic Acid Structure

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

Applications of Molecular Taxonomy

Applications of Molecular Taxonomy

Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

aiSysMet: AI-Powered Systems Metabolomics for Biomarker Discovery.

Bioinformatics (Oxford, England)·2026

Same journal

Large Language Model Ensemble for Automated TNM Staging from Radiology Reports.

Bioinformatics (Oxford, England)·2026

Same journal

damidBind: an R/Bioconductor package for differential DamID analysis and data exploration.

Bioinformatics (Oxford, England)·2026

Same journal

FIERCE: reconstructing dynamic trajectories from the differentiation potency of single cells.

Bioinformatics (Oxford, England)·2026

Same journal

Correction to: The 2024 ISCB Innovator Award-Dr Su-In Lee.

Bioinformatics (Oxford, England)·2026

Same journal

Retraction and replacement of: A deep learning architecture for metabolic pathway prediction.

Bioinformatics (Oxford, England)·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

DV-Curve: a novel intuitive tool for visualizing and analyzing DNA sequences.

Zhu-Jin Zhang¹

¹Key Laboratory of Image Processing and Intelligent Control, Department of Control Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. zhangzhujin@gmail.com

Bioinformatics (Oxford, England)

|March 12, 2009

Summary

The Dual-Vector Curve (DV-Curve) offers a novel graphical method for DNA sequence analysis. This tool effectively visualizes DNA sequences, overcoming limitations of previous methods for mutation and similarity studies.

More Related Videos

Studying DNA Looping by Single-Molecule FRET

Studying DNA Looping by Single-Molecule FRET

Published on: June 28, 2014

Related Experiment Videos

Last Updated: Jun 25, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Studying DNA Looping by Single-Molecule FRET

Studying DNA Looping by Single-Molecule FRET

Published on: June 28, 2014

Area of Science:

Bioinformatics
Computational Biology
Genomics

Background:

The exponential growth of DNA sequence data necessitates advanced visualization tools.
Existing graphical methods struggle with issues like degeneracy, information loss, and visualizing long sequences.

Purpose of the Study:

To introduce a new graphical tool for DNA sequence analysis.
To address the limitations of current visualization methods in bioinformatics.

Main Methods:

Development of the Dual-Vector Curve (DV-Curve) method.
Representing each DNA alphabet with two vectors to avoid degeneracy and information loss.

Main Results:

DV-Curve provides effective visualization for DNA sequences of any length.
The method successfully handles degeneracy and information loss.
Applications in mutation and similarity analyses demonstrate its utility.

Conclusions:

DV-Curve is a significant advancement for visualizing DNA sequences.
This tool aids biologists in uncovering valuable biological insights from sequence data.