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Familial-combined hyperlipidaemia in very young myocardial infarction survivors (< or =40 years of age)
Franz Wiesbauer1, Hermann Blessberger, Danyel Azar
1Department of Cardiology, Vienna General Hospital/Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. franz.wiesbauer@meduniwien.ac.at
European Heart Journal
|March 12, 2009
Summary
Familial-combined hyperlipidaemia (FCHL) significantly increases the risk of myocardial infarction (MI) in individuals under 40. This study found a 24-fold higher risk for young MI patients with the FCHL phenotype.
Area of Science:
- Cardiology
- Genetics
- Metabolic Disorders
Background:
- Myocardial infarction (MI) in individuals under 40 is rare but serious.
- Familial-combined hyperlipidaemia (FCHL) is a known risk factor for MI, but its role in very young patients is unclear.
Purpose of the Study:
- To investigate the prevalence and impact of FCHL in patients under 40 who have experienced MI.
- To determine if FCHL is a significant risk factor for early-onset MI.
Main Methods:
- Prospective enrollment of 102 MI survivors (< or =40 years) and 200 age/gender-matched controls.
- Screening of family members for FCHL using a nomogram based on lipid levels (total cholesterol, triglycerides, Apo B(100)).
Main Results:
- 38% of young MI patients and 2.5% of controls had the FCHL phenotype.
- FCHL was confirmed in 76% of screened families, showing a 24-fold increased adjusted risk for MI.
- VLDL-cholesterol and non-HDL-cholesterol were strongly associated with MI.
Conclusions:
- The FCHL phenotype is a major risk factor for MI at a young age.
- Further research is needed to determine if therapeutic interventions can mitigate this increased risk.
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