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Related Experiment Video

Updated: Jun 25, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Albuminuria in children.

Erin R Rademacher¹, Alan R Sinaiko

¹Division of Pediatric Nephrology, Department of Pediatrics, University of Rochester, Rochester, New York 14642, USA. erin_rademacher@urmc.rochester.edu

Current Opinion in Nephrology and Hypertension

|March 12, 2009

Summary

Albuminuria assessment in children is crucial for predicting future cardiovascular and kidney disease. Early detection in pediatric populations can guide interventions for better long-term health outcomes.

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Area of Science:

Pediatric Nephrology
Cardiovascular Health
Metabolic Disease

Background:

Albuminuria signifies current and future cardiovascular and renal risks in adults.
Early life factors contribute to adult-onset diseases, making pediatric albuminuria assessment relevant.
Understanding pediatric albuminuria is key to preventing long-term morbidity and mortality.

Purpose of the Study:

To review the relevance of albuminuria assessment in child and adolescent clinical care.
To explore the relationship between albuminuria and various health markers in children.
To highlight the need for longitudinal studies in pediatric albuminuria.

Main Methods:

Review of current literature on pediatric albuminuria.
Analysis of factors associated with albuminuria in healthy, obese, and diabetic children.
Examination of clinical predictors and potential mechanisms.

Main Results:

Normal albumin excretion in children is significantly lower than microalbuminuria cut-offs.
In healthy children, albuminuria correlates with fasting insulin.
Obese children show albuminuria linked to insulin resistance; type 1 diabetes shows links to HbA1c; type 2 diabetes and hypertension present with microalbuminuria.

Conclusions:

Children are ideal subjects for studying albuminuria's natural history due to fewer co-morbidities.
The increasing prevalence of 'adult' diseases in children makes this research vital.
Longitudinal studies are needed to identify predictors and treatments for elevated urinary albumin levels.