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Updated: Jun 25, 2026
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Homocysteine increases the risk associated with hyperlipidaemia.
Caroline Daly1, Anthony P Fitzgerald, Patrick O'Callaghan
1Royal Brompton Hospital, Sydney St, London, UK.
Summary
Elevated homocysteine significantly increases cardiovascular disease risk, especially with unfavorable lipid profiles. However, high-density lipoprotein (HDL) cholesterol may offer some protection against these risks.
Area of Science:
- Cardiovascular Science
- Metabolic Health
- Lipidology
Background:
- Elevated homocysteine is a known risk factor for cardiovascular disease (CVD).
- Interactions between homocysteine and lipid subfractions in CVD risk are not fully understood.
- High-density lipoprotein (HDL) cholesterol's potential protective role via paroxonase enzyme activity was hypothesized.
Purpose of the Study:
- To investigate the interplay between homocysteine and individual lipid subfractions in vascular disease.
- To determine if HDL cholesterol mitigates the risks associated with hyperhomocysteinaemia.
Main Methods:
- Analysis of data from a multicentre European case-control study (750 cases, 800 controls).
- Assessment of risks associated with homocysteine, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apoprotein A1, and apoprotein B.
- Examination of how elevated homocysteine modifies cardiovascular risk linked to lipid subfractions.
Main Results:
- Homocysteine, total cholesterol, LDL cholesterol, triglycerides, and apolipoprotein B were linked to increased cardiovascular risk.
- HDL cholesterol showed an inverse relationship with cardiovascular risk.
- Elevated homocysteine amplified the risk associated with all measured lipid parameters.
- Conversely, higher HDL cholesterol levels reduced risk in individuals with elevated homocysteine.
Conclusions:
- Increased cardiovascular risk from elevated homocysteine persists across all cholesterol subfraction levels.
- HDL cholesterol may play a protective role against homocysteine-induced vascular risk.
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