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Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...

High-Performance Liquid Chromatography: Types of Detectors

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...

Prochirality

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

High-Performance Liquid Chromatography: Introduction

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High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
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Molecules with Multiple Chiral Centers

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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

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Related Experiment Video

Updated: Jun 24, 2026

Interfacial Molecular-level Structures of Polymers and Biomacromolecules Revealed via Sum Frequency Generation Vibrational Spectroscopy

Interfacial Molecular-level Structures of Polymers and Biomacromolecules Revealed via Sum Frequency Generation Vibrational Spectroscopy

Published on: August 13, 2019

Chiral detection at a liquid-liquid interface.

Ritu Kataky¹, Paula Lopes

¹Department of Chemistry, University of Durham, Durham, UK DH1 3LE. ritu.kataky@durham.ac.uk

Chemical Communications (Cambridge, England)

|March 12, 2009

Summary

This study explores chiral ion transfer at liquid-liquid interfaces using cyclodextrins for advanced chiral separation. These findings offer novel approaches for chiral detection and analysis.

Area of Science:

Analytical Chemistry
Separation Science
Electrochemistry

Background:

Chiral compounds require specialized separation and detection methods.
Liquid-liquid interfaces present unique challenges and opportunities for ion transfer.
Cyclodextrins are well-established chiral selectors.

Purpose of the Study:

To investigate chiral ion transfer across a liquid-liquid interface.
To evaluate the efficacy of cyclodextrin-based chiral stationary phases in this context.
To explore potential applications in chiral detection and separation.

Main Methods:

Utilizing a liquid-liquid interface setup.
Employing cyclodextrins as chiral stationary phases.
Monitoring ion transfer across the interface.

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Interfacial Molecular-level Structures of Polymers and Biomacromolecules Revealed via Sum Frequency Generation Vibrational Spectroscopy

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Published on: August 13, 2019

A Micropatterning Assay for Measuring Cell Chirality

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Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

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Main Results:

Demonstrated selective chiral ion transfer at the liquid-liquid interface.
Observed distinct transfer behaviors for different enantiomers.
Quantified the influence of cyclodextrin concentration on selectivity.

Conclusions:

Chiral ion transfer at liquid-liquid interfaces is feasible using cyclodextrins.
This method provides a foundation for new chiral separation techniques.
Potential for developing alternative chiral detection systems.