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Impaired splenic function in elderly people.

H S Markus1, P J Toghill

  • 1Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham.

Age and Ageing
|July 1, 1991
PubMed
Summary
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Elderly individuals show reduced splenic function, indicated by more pitted erythrocytes. This impaired spleen function in older adults may increase susceptibility to pneumococcal infections, warranting further investigation.

Area of Science:

  • Gerontology
  • Hematology
  • Immunology

Background:

  • Splenic function declines with age.
  • Pitted erythrocytes are indicators of reduced splenic function.
  • Elderly populations may be at higher risk for infections due to compromised immunity.

Purpose of the Study:

  • To assess splenic function in individuals aged 70 and over.
  • To compare splenic function in elderly versus younger subjects.
  • To investigate the potential link between impaired splenic function and infection risk in the elderly.

Main Methods:

  • Erythrocyte pitting was quantified using differential interference contrast microscopy.
  • A cohort of 40 elderly subjects (≥70 years) was compared to 40 younger subjects.
  • The percentage of pitted erythrocytes was analyzed to determine splenic function.

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Main Results:

  • Elderly subjects had a significantly higher mean percentage of pitted erythrocytes (3.4%) compared to younger subjects (1.6%).
  • Greater variability in splenic function was observed among the elderly.
  • A subgroup of elderly individuals exhibited a markedly increased percentage of pitted erythrocytes.

Conclusions:

  • Splenic function is demonstrably reduced in individuals aged 70 and over.
  • Impaired splenic function in the elderly may elevate the risk of pneumococcal infections.
  • Further research is recommended to explore the relationship between splenic function and infection susceptibility in older adults.