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Paul D Griffiths1, Ruth Batty, Dan A J Connolly

  • 1Academic Unit of Radiology, University of Sheffield, Sheffield, UK. p.griffiths@sheffield.ac.uk

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...