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Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
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Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

Protein kinase C-beta II (PKC-beta II) expression in patients with colorectal cancer

Karen-Lise Garm Spindler1, Jan Lindebjerg, Michael Lahn

  • 1Danish Colorectal Cancer Group South, Vejle Hospital, 7100, Vejle, Denmark. Karen-lise.garm.spindler@vgs.regionsyddanmark.dk

International Journal of Colorectal Disease
|March 12, 2009
PubMed
Abstract

Insights

Protein Kinase C-beta II (PKC-beta II) expression in colorectal cancer shows a trend toward poor prognosis. Further research is needed to evaluate PKC-beta II

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Targeted therapies for colorectal cancer (CRC) are under development, including kinase inhibitors.
  • Protein Kinase C (PKC) and AKT pathways are key signaling routes in cancer.
  • The expression and prognostic significance of PKC-beta in CRC remain largely uncharacterized.

Purpose of the Study:

  • To investigate the expression of PKC-beta II in colorectal adenocarcinomas and lymph node metastases.
  • To determine the prognostic value of PKC-beta II expression in colorectal cancer patients.

Main Methods:

  • Immunohistochemistry (IHC) was used to examine PKC-beta II protein expression in 99 primary colorectal adenocarcinomas and 33 lymph node metastases.
  • PKC-beta II immunoreactivity was correlated with clinicopathological parameters and patient survival data.

Main Results:

  • PKC-beta II expression was detected in 18.2% of colorectal carcinomas.
  • No correlation was found between PKC-beta II staining and traditional clinicopathological parameters.
  • Patients with PKC-beta II expressing tumors had a median survival of 2.2 years versus 5.4 years for negative tumors, indicating a trend toward poor prognosis (p = 0.25).

Conclusions:

  • This study provides the first description of immunohistochemical detection of PKC-beta II in colorectal cancer.
  • A trend suggests that PKC-beta II expression is associated with poorer survival in colorectal cancer patients.
  • The role of PKC-beta II in colorectal tumors warrants further investigation.

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