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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Related Experiment Video

Updated: Jun 24, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systemic sclerosis: a world wide global analysis.

Paola Coral-Alvarado1, Aryce L Pardo, Natalia Castaño-Rodriguez

  • 1Center for Autoimmune Diseases Research (CREA), School of Medicine, Rosario University, Carrera 24 #, 63-C-69, Bogota, Colombia.

Clinical Rheumatology
|March 12, 2009
PubMed
Summary
This summary is machine-generated.

This study reveals global variations in systemic sclerosis (SSc) presentation and occurrence. Factors like ethnicity and geography influence SSc characteristics, highlighting the need for localized research.

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Last Updated: Jun 24, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

  • Rheumatology
  • Epidemiology
  • Genetics

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease with poorly understood global variations.
  • Previous research indicates potential differences in SSc presentation, but comprehensive analysis is lacking.

Purpose of the Study:

  • To analyze global epidemiological tendencies of systemic sclerosis (SSc).
  • To identify local variations in SSc presentation, occurrence, and clinical characteristics worldwide.

Main Methods:

  • Systematic literature review of electronic databases.
  • Keywords used: "Systemic Sclerosis" and "Clinical Characteristics."
  • Analysis of 41 selected articles from an initial pool of 167.

Main Results:

  • Significant regional differences found in mean age at diagnosis for SSc.
  • Variations observed in SSc subsets, clinical manifestations, and autoantibody prevalence across different global regions.
  • Identified geographical and ethnic disparities in SSc epidemiology.

Conclusions:

  • Ethnicity and geography are crucial factors influencing SSc presentation and occurrence.
  • Genetic and environmental variances contribute to population-specific SSc characteristics.
  • Further research should consider these demographic factors in studying SSc and other autoimmune diseases.