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Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in Caenorhabditis elegans

Published on: December 9, 2022

Changes in lipid distribution during aging and its modulation by calorie restriction.

Ji Young Kim¹, Dae Hyun Kim, Jaehun Choi

¹Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung-gu, Busan, 609-735, Korea.

Age (Dordrecht, Netherlands)

|March 12, 2009

Summary

Aging alters fat distribution, decreasing white adipose tissue (WAT) adipogenesis while increasing skeletal muscle fat. Short-term caloric restriction (CR) can modulate these age-related lipid changes.

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Label-Free Imaging of Lipid Storage Dynamics in Caenorhabditis elegans using Stimulated Raman Scattering Microscopy

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Published on: May 28, 2021

Area of Science:

Gerontology
Metabolism
Nutritional Science

Background:

Adipogenesis and ectopic lipid accumulation significantly impact aging and age-related chronic diseases.
Molecular mechanisms of age-related lipid redistribution and nutritional interventions remain poorly understood.

Purpose of the Study:

To investigate the mechanisms of age-related lipid redistribution.
To explore the modulatory effects of caloric restriction (CR) on these age-related changes.

Main Methods:

Utilized male Fischer 344 rats at 5, 17, and 24 months of age.
Compared rats fed ad libitum (AL) with those on a 3-week short-term caloric restriction (CR) diet (40% less than AL).
Assessed adipogenic transcription factor activity in white adipose tissue (WAT) and carnitine palmitoyltransferase-1 activity in skeletal muscle.

Main Results:

Aged rats on AL diet showed decreased adipogenic transcription factor activity in WAT.
Skeletal muscle of aged AL rats exhibited increased fat accumulation due to reduced carnitine palmitoyltransferase-1 activity.
Short-term CR blunted the age-related decrease in carnitine palmitoyltransferase-1 activity and subsequent ectopic lipid accumulation.

Conclusions:

Aging promotes a shift in lipid distribution, characterized by reduced WAT adipogenesis and increased intramyocellular lipid accumulation.
Short-term caloric restriction demonstrates potential in modulating age-related changes in adipogenesis and ectopic lipid accumulation.