Capillary NMR detection in separation science
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Updated: Feb 17, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
Maximilian Kühnle1, Karsten Holtin, Klaus Albert
1Institute of Organic Chemistry, University of Tuebingen, Tuebingen, Germany.
Abstract:
This review deals with the current status of important separation techniques using capillary NMR detection. The advantages and disadvantages of the different hyphenated methods are discussed referring to a specific application. The use of Capillary-HPLC-NMR is demonstrated on an identification method of two bixin stereoisomers. The huge advantages using an HPLC-SPE-NMR method for structure determination are explained and discussed. Furthermore, two uncommon coupling techniques such as CE-NMR and GC-NMR are described in this review article.
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