[Analysis of primary diseases of 452 patients complicated by multiple organs dysfunction syndrome]

To investigate the influence of the primary diseases on the outlook of multiple organs dysfunction syndrome (MODS).

The investigation was a multicentre study. The clinical data of 452 MODS cases from 20 III-level general hospitals in Northern China were analyzed with chi-square test and logistic regression analysis. The relationship of primary diseases, their distribution and prognosis of MODS was investigated.

Mean age of patients (320 cases) who were suffering from a certain disease was (67.9+/-0.8) years old, which was higher than that of patients [132 cases, (46.9+/-1.7) years old] who did not have a primary disease (P=0.000). The mortality of patients with existing primary diseases was 56.2% (180/320), which was higher than that of the patients without a primary disease (31.1%, 41/132, P=0.000). The percent of occurrence of dysfunction of three organs was higher in patients who were suffering from some primary diseases was 74.38% (238 cases) than that of those without a primary disease (63.64%, 84 cases, P=0.022). In the patients who were suffering from cerebrovascular disease, cardiac insufficiency, chronic obstructive pulmonary disease (COPD), the incidence of complicating with dysfunction of three to four organs was respectively 63.4% (52/82), 67.1% (55/82), 69.1% (38/55), and were higher than those patients who did not have above-mentioned diseases [50.5% (187/370), 49.7% (184/370), 54.3% (201/370), all P<0.05]. Logistic regression analysis showed that cerebrovascular disease was the major risk factor.

In patients whose age is over 67 years, and at the same time they are having a primary disease, the prognosis is poor. The mortality of MODS patients with hypertension, cerebrovascular disease, cardiac insufficiency, COPD, chronic renal insufficiency is higher, and cerebrovascular disease is the major risk factor in the prognosis of MODS patients.