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Related Experiment Video

Updated: Jun 24, 2026

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

Preventing diabetic complications: a primary care perspective.

¹Baker IDI Heart and Diabetes Institute, 250 Kooyong Road, Caulfield, Victoria 3162, Australia. Paul.Zimmet@bakeridi.edu.au

Diabetes Research and Clinical Practice

|March 13, 2009

Summary

Fenofibrate significantly reduced cardiovascular events and microvascular complications in diabetes patients, particularly those with abnormal lipid profiles. This suggests fenofibrate is a valuable option for managing diabetic vascular complications.

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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

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Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

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Published on: July 14, 2023

Area of Science:

Cardiology
Endocrinology
Diabetology

Background:

Cardiometabolic risk factor control is key in diabetes management.
Despite intensive treatment of glucose, blood pressure, and lipids, significant disease burden persists.
The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study offers new insights.

Purpose of the Study:

To evaluate the effects of fenofibrate on cardiovascular and microvascular outcomes in patients with diabetes.
To assess fenofibrate's role in managing diabetic vascular complications.

Main Methods:

Analysis of data from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study.
Evaluation of cardiovascular events and microvascular outcomes in participants treated with fenofibrate.

Main Results:

Fenofibrate significantly reduced total cardiovascular disease events.
A notable reduction in events was observed in patients with atherogenic dyslipidemia (low HDL, high triglycerides).
Fenofibrate demonstrated preventive effects on microvascular outcomes, including retinopathy, albuminuria progression, and amputations.

Conclusions:

Fenofibrate effectively reduces cardiovascular events in diabetic patients, especially those with dyslipidemia.
Fenofibrate shows significant benefits in preventing microvascular complications associated with diabetes.
Re-evaluation of fenofibrate is warranted as a therapeutic option for reducing diabetic vascular complications.