Related Experiment Video
Updated: Jun 24, 2026

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
Published on: August 13, 2017
Protein phosphatase 2A in Alzheimer's disease
1Department of Pathophysiology, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
Abstract:
Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells. In Alzheimer's disease (AD), PP2A activity is decreased. Decreased PP2A activity is suggested to be involved in NFT formation and neurodegeneration. PP2A is also involved in APP secreting pathway, thus probably participating the Abeta production. Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation could partly explain the mechanisms of PP2A inactivation in AD. Abeta over-production, estrogen deficiency and impaired homocysteine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons. Further studies are needed to disclose the role of PP2A in Alzheimer's disease.
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Protein Kinases and Phosphatases
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Alzheimer's Disease: Treatment
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Phosphorylation
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
