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Hypertension in the elderly patient
1San Francisco Heart Institute, Daly City, CA 94015.
Insights
Treating hypertension in elderly individuals significantly lowers cardiovascular disease and stroke risks. Ongoing trials like SHEP and STH aim to further clarify treatment benefits for isolated systolic hypertension in older adults.
Area of Science:
- Gerontology
- Cardiovascular Medicine
- Clinical Trials
Background:
- Elderly individuals with hypertension face increased risks of cardiovascular disease and stroke.
- Diastolic hypertension treatment in the elderly shows reduced cardiovascular morbidity.
- Isolated systolic hypertension in older adults is strongly linked to stroke and cardiovascular mortality.
Purpose of the Study:
- To review the impact of hypertension treatment on cardiovascular and cerebrovascular outcomes in the elderly.
- To highlight the unique mechanisms of hypertension in older populations, such as peripheral vascular resistance.
- To discuss ongoing research, including the Systolic Hypertension European trial and the Systolic Hypertension in the Elderly Patient trial.
Main Methods:
- Review of existing clinical trial data on hypertension treatment in elderly patients.
- Analysis of the relationship between isolated systolic hypertension and adverse cardiovascular and cerebrovascular events.
- Discussion of the physiological mechanisms underlying hypertension in the elderly.
Main Results:
- Treatment of diastolic hypertension in the elderly reduces cardiovascular morbidity.
- Treatment in the Systolic Hypertension in the Elderly Patient pilot trial reduced stroke morbidity and mortality.
- Isolated systolic hypertension presents a significant risk for stroke and cardiovascular disease in older adults.
Conclusions:
- Hypertension management is crucial for reducing morbidity and mortality in elderly patients.
- Further research from ongoing trials is needed to fully understand the treatment of isolated systolic hypertension in this population.
- Peripheral vascular resistance is a key factor in elderly hypertension, and exercise may help reduce it.
Abstract:
Several trials have demonstrated a significant reduction in morbidity from cardiovascular disease with the treatment of diastolic hypertension in elderly persons. The pilot trial of the Systolic Hypertension in the Elderly Patient study showed a reduction in morbidity and mortality from stroke with less of a reduction in death from cardiac conditions in elderly patients who were treated. Isolated systolic hypertension in elderly persons has a particularly hazardous connection with morbidity and mortality from stroke and cardiovascular disease. The mechanisms of hypertension are different, if not greatly so, in the elderly population. Peripheral vascular resistance plays a major role. However, reduction in peripheral vascular resistance can still be demonstrated with exercise in older patients. Two major studies are ongoing--the Systolic Hypertension European trial and the Systolic Hypertension in the Elderly Patient trial. We await the outcome of these trials to learn more about the treatment of isolated systolic hypertension in elderly patients.
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