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Blood pressure follows the kidney: Perinatal influences on hereditary hypertension

Maarten P Koeners1, Branko Braam, Jaap A Joles

  • 1Department of Nephrology and Hypertension; University Medical Center; Utrecht The Netherlands.

Organogenesis
|March 13, 2009
PubMed

Insights

Perinatal programming, originating from aberrant fetal development, can lead to cardiovascular diseases. Reprogramming renal development offers a potential strategy to persistently ameliorate hereditary hypertension.

Area of Science:

  • Cardiovascular physiology and developmental biology.

Background:

  • Cardiovascular diseases may stem from abnormal fetal development, a process termed perinatal programming.
  • The kidneys play a crucial role in regulating blood pressure throughout life.

Purpose of the Study:

  • To review the role of renal development in blood pressure regulation.
  • To explore the potential of reprogramming renal development to treat hereditary hypertension.

Main Methods:

  • Combines physiological and genomic studies.
  • Identifies candidate pathways for intervention.

Main Results:

  • Discovery of potential pathways for reprogramming renal development.
  • Suggests a link between renal programming and hypertension amelioration.

Conclusions:

  • Renal development reprogramming is a promising avenue for treating hereditary hypertension.
  • Further mechanistic studies are warranted to validate identified pathways.

Keywords:
citrullinehypertensionnitric oxideperinatal developmentspontaneously hypertensive rat

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