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Related Experiment Videos

How much vitamin D for neonates?

W B Pittard1, K M Geddes, T C Hulsey

  • 1Department of Pediatrics, Medical University of South Carolina, Charleston 29425-3313.

American Journal of Diseases of Children (1960)
|October 1, 1991
PubMed
Summary
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Ten micrograms (400 IU) of vitamin D daily is adequate for both premature and full-term infants. Lower doses of 25-hydroxyvitamin D3 may suffice for low-birth-weight neonates but not full-term infants.

Area of Science:

  • Neonatal nutrition
  • Pediatric endocrinology
  • Vitamin D metabolism

Background:

  • Vitamin D is crucial for infant health, but optimal neonatal dosages are debated.
  • Assessing vitamin D sufficiency requires monitoring serum 25-hydroxyvitamin D levels.
  • Premature and full-term infants may have different nutritional requirements.

Purpose of the Study:

  • To determine adequate neonatal vitamin D and 25-hydroxyvitamin D3 dosages.
  • To compare vitamin D status in low-birth-weight versus full-term infants.
  • To establish optimal supplementation strategies for diverse infant populations.

Main Methods:

  • Longitudinal monitoring of 25-hydroxyvitamin D serum concentrations in 52 infants (27 low-birth-weight, 25 full-term).
  • Randomized assignment to receive daily vitamin D (10 or 20 micrograms) or 25-hydroxyvitamin D3 (0.85 or 1.5 micrograms).

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  • Monitoring occurred from birth to 16 weeks postpartum.

    • Main Results:

    • Infants receiving 10 or 20 micrograms/d of vitamin D maintained serum concentrations >20 ng/mL.
    • Low-birth-weight infants on 0.85 or 1.5 micrograms/d of 25-hydroxyvitamin D3 maintained levels >12 ng/mL.
    • Full-term infants on 1.5 micrograms/d of 25-hydroxyvitamin D3 maintained levels >12 ng/mL, but not on 0.85 micrograms/d.

    Conclusions:

    • 10 micrograms (400 IU) of vitamin D daily is sufficient for both premature and full-term infants.
    • 0.85 micrograms/d of 25-hydroxyvitamin D3 may support vitamin D sufficiency in low-birth-weight neonates.
    • 0.85 micrograms/d of 25-hydroxyvitamin D3 is insufficient for maintaining vitamin D sufficiency in full-term infants.