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Cerebral venous thrombosis in Behçet's disease compared to those associated with other etiologies

N Yesilot1, S Bahar, S Yilmazer

  • 1Department of Neurology, Istanbul Medical School, Capa, 34293 Istanbul, Turkey. niluferyes@yahoo.com

Journal of Neurology
|March 13, 2009
PubMed

Insights

Cerebral venous thrombosis (CVT) associated with Behçet's disease (BD) presents differently than other causes, often with subacute onset and intracranial hypertension. CVT patients with BD generally have better outcomes and rarely develop venous infarction.

Area of Science:

  • Neurology
  • Rheumatology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) has diverse causes.
  • Behçet's disease (BD) is a significant cause of CVT in Mediterranean and Middle Eastern populations.

Purpose of the Study:

  • To compare clinical and radiological characteristics of CVT in patients with and without Behçet's disease.
  • To identify distinguishing features of CVT associated with BD.

Main Methods:

  • Retrospective evaluation of CVT patients.
  • Comparison of clinical, neuroradiological, and follow-up data between BD and non-BD CVT groups.
  • Statistical analysis of demographic and clinical variables.

Main Results:

  • BD patients were younger (median 26 vs. 39 years) and predominantly male compared to non-BD patients.
  • CVT in BD typically presented with subacute onset and isolated intracranial hypertension (94%), unlike acute onset in non-BD.
  • Venous infarcts were rare in BD (6%) versus common in non-BD (63%).
  • Outcomes were favorable in all BD patients (mRS 0-2 in 97%) versus 91% in non-BD.

Conclusions:

  • CVT associated with Behçet's disease exhibits distinct features, including subacute onset, isolated intracranial hypertension, and a low incidence of venous infarction.
  • These characteristics differentiate BD-associated CVT from CVT due to other etiologies.
  • CVT in BD patients generally has a good prognosis.

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