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Updated: Jun 24, 2026

Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli
Published on: April 20, 2021
Electrochemical quantification of reactive oxygen and nitrogen: challenges and opportunities
1Biologisch-Chemische Mikrostrukturtechnik, Fakultät Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany. sabine.borgmann@tu-dortmund.de
Abstract:
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a crucial role in chemical signaling processes of biological cells. Electrochemistry is one of the rare methods able to directly detect these species. ROS and RNS can be monitored in the local microenvironment of cells in real time at the site where the actual signaling takes place. This review presents recent advances made with amperometric electrochemical techniques. Existing challenges for the quantification of ROS and RNS in biological systems are discussed to promote the development of innovative and reliable cell-based assays.
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