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Updated: Jun 24, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Genetic and environmental mediation of the associations between self-rated health and cognitive abilities
Pia Svedberg1, Margaret Gatz, Nancy L Pedersen
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Pia.Svedberg@ki.se
Abstract:
This study examined the relationship between self-rated health and cognitive abilities. First, the authors investigated whether common complex diseases mediate the associations between self-rated health and cognitive abilities. Slight evidence was found that associations between self-rated health and cognitive test scores were mediated by chronic diseases. Second, the authors explored the genetic and environmental mediation of these relationships using bivariate quantitative genetic analyses. In the younger age group (<67 years), associations between self-rated health and spatial reasoning and perceptual speed were mediated by both genetic and nonshared environmental factors. In the oldest age group (>or=67 years), associations between self-rated health and spatial reasoning, perceptual speed, and visual memory were entirely due to genetic factors.
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