Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 24, 2026

Electric and Magnetic Field Devices for Stimulation of Biological Tissues
13:29

Electric and Magnetic Field Devices for Stimulation of Biological Tissues

Published on: May 15, 2021

Can low frequency electromagnetic field help cartilage tissue engineering?

Chih-Hung Chang1, Siow-Tung Loo, Hsuan-Liang Liu

  • 1Division of Orthopedics, Department of Surgery, Far Eastern Memorial Hospital, Pan-Chiao, Taiwan.

Journal of Biomedical Materials Research. Part A
|March 13, 2009
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered EEG microstate dynamics as a neurophysiological biomarker for diagnostic differentiation in Schizophrenia.

Psychiatry research. Neuroimaging·2026
Same author

Chitosan/Fe<sub>3</sub>O<sub>4</sub>/graphene nanoplatelets composites-modified glassy carbon electrode for highly sensitive electrochemical detection of dopamine, uric acid, and ascorbic acid.

Carbohydrate polymers·2026
Same author

Development of an Inventory to Identify Psychosocial Factors Influencing Hand Usage: the CHUC.

medRxiv : the preprint server for health sciences·2026
Same author

Addressing Current Challenges in Hydrogel Wound Dressing Strategies for Chronic Wound Management: Advances and Future Directions.

Journal of biomedical materials research. Part B, Applied biomaterials·2026
Same author

The investigation of the inhibition effects of substituting Mg<sup>2+</sup> with Ca<sup>2+</sup> and Zn<sup>2+</sup> on SARS-CoV-2 RNA-dependent RNA polymerase.

Journal of biomolecular structure & dynamics·2026
Same author

Impact of Metabolic Associated Steatotic Liver Disease on Antiviral Therapy Outcomes on Chronic Hepatitis B Patients Receiving Antiviral Therapy.

Journal of medical virology·2026

Low-frequency pulsed electromagnetic field (EMF) exposure enhanced chondrocyte proliferation and gene expression in collagen constructs. While initially boosting glycosaminoglycan (GAG) production, long-term GAG and collagen II/X production showed no significant increase.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Cartilage tissue engineering aims to repair damaged cartilage.
  • Electromagnetic fields (EMF) are being explored for their potential therapeutic effects.
  • Understanding EMF's impact on chondrocytes and collagen is crucial for developing effective tissue engineering strategies.

Purpose of the Study:

  • To investigate the effects of low-frequency pulsed electromagnetic field (EMF) on collagen gel properties and chondrocyte behavior.
  • To assess EMF's potential to aid cartilage repair within tissue engineering scaffolds.

Main Methods:

  • Primary chondrocytes were embedded in collagen gel and exposed to EMF for 24 hours.
  • Control groups were not exposed to EMF.

More Related Videos

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

Mechanical Stimulation of Chondrocyte-agarose Hydrogels
12:45

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Published on: October 27, 2012

Related Experiment Videos

Last Updated: Jun 24, 2026

Electric and Magnetic Field Devices for Stimulation of Biological Tissues
13:29

Electric and Magnetic Field Devices for Stimulation of Biological Tissues

Published on: May 15, 2021

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

Mechanical Stimulation of Chondrocyte-agarose Hydrogels
12:45

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Published on: October 27, 2012

  • Cell proliferation, glycosaminoglycan (GAG) production, and gene expression (aggrecan, collagen types I, II, X) were analyzed post-exposure.

    • Main Results:

    • EMF exposure increased collagen gel hydrophobicity and reduced enzymatic degradation.
    • Chondrocytes exhibited higher proliferation and gene expression for aggrecan and collagen types I and X after EMF exposure.
    • Short-term (1 week) GAG production and lacuna formation were enhanced, but no significant GAG or collagen II/X production was observed in histological staining at 3 weeks.

    Conclusions:

    • A single EMF exposure can promote chondrocyte proliferation and gene expression in collagen-based tissue engineering constructs.
    • EMF shows potential for short-term enhancement of cartilage matrix components.
    • Further research is needed to optimize EMF parameters for sustained cartilage matrix production and repair.