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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Introduction to Connective Tissues01:11

Introduction to Connective Tissues

Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts, osteocytes,...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: Jun 24, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

[B lymphocyte abnormalities in connective tissue disorders].

Shinichi Sato1

  • 1Department of Dermatology, Nagasaki University, Graduate School of Biomedical Sciences.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 14, 2009
PubMed
Summary
This summary is machine-generated.

B lymphocytes, or B cells, are crucial for immune regulation beyond antibody production. Their roles in antigen presentation and cytokine release impact autoimmune disease development, prompting new targeted therapies.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

  • Immunology
  • Autoimmunity
  • Cell Biology

Background:

  • B lymphocytes (B cells) are traditionally known for antibody secretion.
  • Emerging evidence highlights B cells' broader roles in immune system regulation.
  • Dysfunctional B cell activity is implicated in the pathogenesis of systemic autoimmune disorders.

Purpose of the Study:

  • To elucidate the multifaceted functions of B cells in immune responses.
  • To explore the contribution of B cell abnormalities to autoimmunity.
  • To underscore the therapeutic potential of targeting B cells in autoimmune diseases.

Main Methods:

  • Review of existing literature on B cell immunobiology.
  • Analysis of B cell roles in antigen presentation and cytokine production.
  • Examination of B cell involvement in systemic autoimmune conditions.

Main Results:

  • B cells function as potent antigen-presenting cells.
  • B cells produce a variety of immunomodulatory cytokines.
  • B cells influence T effector cell differentiation and function.
  • Aberrant B cell functions are linked to the initiation and progression of autoimmunity.

Conclusions:

  • B cells possess critical regulatory functions beyond antibody secretion.
  • Understanding these functions is key to comprehending systemic autoimmunity.
  • Targeting B cells represents a promising therapeutic strategy for connective tissue disorders and other autoimmune conditions.