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Updated: Jun 24, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Published on: June 15, 2018

[Intravenous immunoglobulin (IVIG)].

Masako Hara1

  • 1Institute of Rheumatology, Tokyo Women's Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 14, 2009
PubMed
Summary
This summary is machine-generated.

Intravenous immunoglobulin (IVIG) effectively treats various autoimmune and neurological conditions like ITP and CIDP. This therapy offers benefits for collagen diseases, though potential complications require consideration.

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Area of Science:

  • Immunology
  • Neurology
  • Rheumatology

Context:

  • Intravenous immunoglobulin (IVIG) therapy, first used for idiopathic thrombocytopenic purpura (ITP) in 1981, has expanded to treat numerous autoimmune conditions.
  • Controlled trials have confirmed IVIG efficacy in ITP, Guillain-Barré syndrome, chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multiple sclerosis, myasthenia gravis, ANCA-associated vasculitis, Kawasaki disease, autoimmune uveitis, and dermatomyositis.
  • Uncontrolled trials and case reports suggest potential benefits of IVIG in connective tissue diseases, including systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, antiphospholipid antibody syndrome, and Still's disease.

Purpose:

  • To summarize the applications of IVIG in collagen diseases.
  • To review the novel mechanisms of action for IVIG therapy.
  • To discuss the potential complications associated with IVIG treatment.

Summary:

  • IVIG has demonstrated efficacy in several autoimmune and neurological disorders through controlled trials.
  • Evidence for IVIG in connective tissue diseases is primarily from uncontrolled studies and case reports.
  • Insurance coverage for IVIG in Japan is limited to ITP, Kawasaki disease, and CIDP.

Impact:

  • IVIG represents a significant therapeutic option for a range of immune-mediated diseases.
  • Understanding IVIG's mechanisms and complications is crucial for optimizing patient care.
  • Further research may elucidate broader applications of IVIG in rheumatological conditions.