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Poly(ortho ester amides): acid-labile temperature-responsive copolymers for potential biomedical applications.

Rupei Tang¹, R Noelle Palumbo, Weihang Ji

¹Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street Southeast, Minneapolis, Minnesota 55455, USA.

Biomacromolecules

|March 14, 2009

Summary

Researchers developed a new method to create poly(ortho ester amide) (POEA) copolymers. These novel materials exhibit temperature-responsive, acid-labile properties, showing potential for controlled drug delivery systems.

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Published on: February 27, 2016

Area of Science:

Polymer Chemistry
Materials Science
Biomedical Engineering

Background:

Traditional synthesis of poly(ortho esters) has limitations.
Stimuli-responsive polymers are crucial for advanced drug delivery.

Purpose of the Study:

To develop a convenient synthesis pathway for hydrolytically labile poly(ortho ester amide) (POEA) copolymers.
To investigate the stimuli-responsive properties and potential biomedical applications of these novel POEA copolymers.

Main Methods:

Synthesized a diamine monomer with a stabilized ortho ester group.
Polycondensation of the diamine with diacid esters to form POEA copolymers.
Investigated temperature-responsive sol-gel transitions, phase behavior in water, polymer erosion kinetics, and drug release profiles.

Main Results:

Developed a convenient synthesis for POEA copolymers with unique stimuli-responsive properties.
POEA copolymers exhibit temperature-responsive, reversible sol-gel phase transitions in water, tunable by monomer selection.
Demonstrated near zero-order kinetics for polymer erosion and drug release, with faster rates at pH 5.0 compared to pH 7.4.
Showed no cytotoxicity, indicating biocompatibility.

Conclusions:

Novel acid-labile, temperature-responsive POEA copolymers were successfully synthesized.
These POEA copolymers demonstrate potential for biomedical applications, particularly in minimal invasive, controlled-release drug delivery systems.
The materials respond to biological temperature and acidic pH environments, making them suitable for targeted delivery.