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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Videos

Crescentic glomerulonephritis associated with miliary tuberculosis.

Y K Wen1, M L Chen

  • 1Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan. 45440@cch.org.tw

Clinical Nephrology
|March 14, 2009
PubMed
Summary
This summary is machine-generated.

Disseminated tuberculosis in a 70-year-old man caused rare immune complex-mediated glomerulonephritis and acute kidney injury. Treatment with antitubercular agents led to renal function recovery.

Related Experiment Videos

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Tuberculosis (TB) is a significant global health issue.
  • Glomerulonephritis (GN) is a kidney disease affecting the glomeruli.
  • The association between TB and GN is exceptionally rare.

Observation:

  • A 70-year-old male presented with cervical lymphadenopathy, hypercalcemia, and acute renal failure.
  • Lymph node biopsy showed caseating granulomas, indicative of tuberculosis.
  • Renal biopsy revealed immune complex-mediated diffuse proliferative glomerulonephritis with crescent formation.

Findings:

  • Disseminated Mycobacterium tuberculosis infection was confirmed through cultures.
  • The patient's glomerular disease exhibited ultrastructural features consistent with infectious glomerulonephritis.
  • Successful treatment of disseminated tuberculosis with antitubercular agents resulted in the recovery of renal function.

Implications:

  • This case highlights an extremely rare presentation of disseminated tuberculosis causing glomerulonephritis.
  • It underscores the importance of considering infectious etiologies in unexplained renal disease.
  • The findings contribute to the limited literature on tuberculosis-associated glomerulonephritis, emphasizing the need for prompt diagnosis and treatment.