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Updated: Jun 24, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Progressive renal failure as the first manifestation of monoclonal light-chain deposition disease with rapid multiple
G Pérez-Suárez1, J M Raya, A Alvarez
1Department of Nephrology, Hospital Universitario de Canarias, Tenerife, Spain. gpersuarez@gmail.com
Abstract:
Light-chain deposition disease (LCDD) is an uncommon condition in which monoclonal light chains are deposited in different organs causing varying degrees of tissue damage. We report the case of a 56-year-old male with progressive renal failure as the first manifestation of LCDD without initial evidence of monoclonal immunoglobulin protein in either serum or urine. The patient later developed severe systemic disease with rapid multiple organ involvement. Finally, he died 2 months after diagnosis, despite steroid and cyclophosphamide therapy.
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