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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

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Related Experiment Video

Updated: Jun 24, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Skin and soft tissue infections.

Addison K May1

  • 1Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA. addison.may@vanderbilt.edu

The Surgical Clinics of North America
|March 14, 2009
PubMed
Summary

Skin and soft tissue infections require prompt diagnosis and treatment to prevent disability. Differentiating necrotizing from non-necrotizing infections is crucial for effective surgical and antibiotic therapy.

Area of Science:

  • Infectious Diseases
  • Surgical Infections
  • Antimicrobial Therapy

Background:

  • Skin and soft tissue infections (SSTIs) are a frequent reason for hospitalization and antibiotic use.
  • These infections can lead to substantial patient disability.
  • Surgical management of SSTIs ranges from simple cellulitis to severe necrotizing infections.

Purpose of the Study:

  • To emphasize the critical importance of distinguishing necrotizing from non-necrotizing soft tissue infections.
  • To highlight the need for understanding evolving SSTI epidemiology for appropriate empiric antibiotic selection.

Main Methods:

  • This study focuses on the clinical and epidemiological aspects of skin and soft tissue infections.
  • It reviews the critical differences in management between necrotizing and non-necrotizing SSTIs.

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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

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Last Updated: Jun 24, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
10:45

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

Published on: June 13, 2018

  • Emphasis is placed on the role of surgical intervention and antibiotic therapy.

    • Main Results:

    • Accurate differentiation between necrotizing and non-necrotizing infections is essential for successful surgical treatment.
    • Understanding current epidemiological trends in SSTIs is vital for guiding empiric antibiotic choices.

    Conclusions:

    • Effective management of SSTIs hinges on precise diagnosis and timely intervention.
    • Appropriate surgical therapy and informed antibiotic selection, guided by epidemiology, are key to improving patient outcomes and reducing disability.