Related Experiment Video
Updated: Jun 24, 2026

Ganglioside Extraction, Purification and Profiling
Published on: March 12, 2021
Synthesis of the starfish ganglioside LLG-3 tetrasaccharide
Shinya Hanashima1, Daichi Ishikawa, Shoji Akai
1Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, Kanagawa, Japan.
Abstract:
The first synthesis of the ganglioside LLG-3 tetrasaccharide, which has attractive biological activities as well as a unique structure, is described. A C8-methoxy decorated sialic acid building block was initially prepared and a glycolic acid moiety was then introduced by sialylation. Amide condensation between the sialyl glycolic acid and an amino group at C5 on the sialyllactoside unit afforded the fully protected LLG-3 tetrasaccharide. Finally, the desired tetrasaccharide part of LLG-3 was obtained after careful global deprotection. [structure: see text].
Related Concept Videos
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Formation of Lipopolysaccharides
Proteoglycans
Peptidoglycan Synthesis
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Protein Glycosylation
Glycosylation occurs in...

