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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...

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Related Experiment Video

Updated: Jun 24, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

H2A.Z and DNA methylation: irreconcilable differences.

Michael S Kobor1, Matthew C Lorincz

  • 1Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28(th) Avenue, Vancouver, BC V5Z 4H4, Canada.

Trends in Biochemical Sciences
|March 14, 2009
PubMed
Summary
This summary is machine-generated.

Histone variant H2A.Z occupancy and DNA methylation show an antagonistic relationship in Arabidopsis. This study reveals how histone variants influence DNA methylation and chromatin structure.

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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina

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Last Updated: Jun 24, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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Area of Science:

  • Epigenetics
  • Molecular Biology
  • Plant Science

Background:

  • DNA methylation and nucleosome composition regulate chromatin structure and gene transcription.
  • Chromatin remodeling and histone modifications influence DNA methylation in plants and animals.
  • The role of histone variants in directing DNA methylation is largely unaddressed.

Purpose of the Study:

  • Investigate the relationship between histone variants and DNA methylation genome-wide.
  • Determine if histone variants direct DNA methylation or vice versa.
  • Understand the interplay between H2A.Z occupancy and DNA methylation patterns.

Main Methods:

  • Genome-wide study in Arabidopsis thaliana.
  • Analysis of H2A.Z occupancy and DNA methylation patterns.
  • Computational biology approaches to assess correlations.

Main Results:

  • A broadly antagonistic relationship was observed between H2A.Z occupancy and DNA methylation.
  • H2A.Z occupancy is generally inversely correlated with DNA methylation levels.
  • The findings suggest a regulatory role for H2A.Z in DNA methylation.

Conclusions:

  • Histone variant H2A.Z plays a significant role in regulating DNA methylation in Arabidopsis.
  • The study uncovers a novel epigenetic crosstalk between histone variants and DNA methylation.
  • This finding advances our understanding of chromatin regulation and transcriptional control.