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Published on: February 7, 2017
Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization
Ana Carolina C Asbahr1, Luzia Franco, Andersson Barison
1Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 632, Curitiba, PR 80210-170, Brazil. acasbahr@hotmail.com
Abstract:
The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.
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