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Related Experiment Videos

Enhanced neutrophil function in children on bromide therapy.

R W Steele1, R C Woody, R W Steele

  • 1Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.

The American Journal of the Medical Sciences
|September 1, 1991
PubMed
Summary

Bromide therapy in children enhances neutrophil function, boosting bacterial killing. Higher bromide levels initially increase, then decrease, this immune response, suggesting a therapeutic window for optimal host defense.

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Area of Science:

  • Immunology
  • Pharmacology

Background:

  • Neutrophil bacterial killing involves toxic halide complex formation.
  • Bromide (Br-) is used in anticonvulsant therapy.

Purpose of the Study:

  • To investigate neutrophil function in children undergoing bromide therapy.
  • To determine the relationship between serum bromide concentrations and neutrophil activity.

Main Methods:

  • Collected whole blood and serum from 7 patients on bromide elixir.
  • Measured neutrophil function using luminol-enhanced chemiluminescence (CL).
  • Determined serum bromide concentrations ([Br-]).

Main Results:

  • A direct correlation (r=0.87) was observed between [Br-] and neutrophil CL activity.

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  • Peak CL responses were higher than controls within the therapeutic [Br-] range (10-20 mM).
  • In vitro addition of Br- to control neutrophils dose-dependently enhanced CL activity, with optimal enhancement at 30 mM.

    • Conclusions:

    • Bromide ions enhance neutrophil phagocytic and bactericidal activity.
    • Bromide therapy may potentially augment host defense capabilities against bacterial infections.