Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary pulmonary hypertension.

M T Olivari1

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9047.

The American Journal of the Medical Sciences
|September 1, 1991
PubMed
Summary

Primary pulmonary hypertension (PPH) is a rare, often fatal disease affecting young adults. While treatments can ease symptoms, they do not improve survival, making lung transplantation a critical option for some patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Behavioral and environmental factors contributing to the development and progression of congestive heart failure.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2000
Same author

Cardiac transplantation in patients with refractory ventricular arrhythmias.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2000
Same author

Chronic endothelin blockade in dogs with pacing-induced heart failure: possible modulation of sympathoexcitation.

Journal of cardiac failure·2000
Same author

Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure.

Circulation·1999
Same author

Cardiac transplantation: a review of indications and results.

Cardiologia (Rome, Italy)·1998
Same author

Usefulness of surveillance endomyocardial biopsy after pediatric cardiac transplantation.

Clinical transplantation·1998

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Research

Background:

  • Primary pulmonary hypertension (PPH) is a rare disease with unknown causes.
  • It predominantly affects individuals in their third and fourth decades of life.
  • Despite variable clinical presentations and rare spontaneous regressions, PPH is associated with poor survival rates, averaging three years post-diagnosis.

Purpose of the Study:

  • To review the current understanding of primary pulmonary hypertension.
  • To discuss the efficacy of existing treatments for PPH.
  • To highlight the role of lung transplantation in managing advanced PPH.

Main Methods:

  • Literature review of primary pulmonary hypertension.
  • Analysis of clinical outcomes and treatment responses.
  • Evaluation of survival data and transplantation as a therapeutic option.

Main Results:

  • Vasodilator therapies, including calcium channel blockers and prostaglandins, can alleviate PPH symptoms.
  • Current medical treatments have not demonstrated a significant improvement in survival rates for PPH patients.
  • Lung transplantation offers a potential avenue for improved function and survival in select, deteriorating PPH cases.

Conclusions:

  • PPH remains a challenging diagnosis with limited long-term survival.
  • Medical management primarily focuses on symptom control.
  • Lung transplantation is a vital consideration for eligible patients with progressive PPH unresponsive to medical therapy.

Related Experiment Videos