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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Chk1 phosphorylation during mitosis: a new role for a master regulator

Deborah Wilsker1, Fred Bunz

  • 1Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Cell Cycle (Georgetown, Tex.)
|March 14, 2009
PubMed
Summary

Essential DNA damage response proteins, like Chk1 and ATR, are crucial for cell survival, unlike nonessential ATM and p53. Understanding their roles in undamaged cells is key to comprehending cell cycle regulation and cancer prevention.

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