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Related Experiment Videos

Microbiologic aspects of fluoroquinolones.

H C Neu1

  • 1Division of Infectious Diseases, College of Physicians & Surgeons of Columbia University, New York, N.Y.

American Journal of Ophthalmology
|October 1, 1991
PubMed
Summary

Fluoroquinolones, including nalidixic acid and newer agents, are effective antimicrobial drugs. This review covers their chemistry, activity, pharmacology, and clinical applications for various infections.

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Microbiology

Background:

  • Fluoroquinolones represent a class of antimicrobial agents with a history dating back to nalidixic acid in 1962.
  • Newer fluoroquinolone development and usage surged in the late 1980s.
  • Extensive use of oral fluoroquinolones for community and hospital infections has been noted in Japan and Europe.

Purpose of the Study:

  • To provide a comprehensive review of fluoroquinolone antibiotics.
  • To cover the chemistry, antimicrobial activity, pharmacology, and clinical applications of fluoroquinolones.

Main Methods:

  • Literature review of fluoroquinolone research and clinical data.
  • Synthesis of information on chemical properties, antimicrobial spectrum, pharmacokinetic profiles, and therapeutic uses.

Main Results:

  • Fluoroquinolones exhibit broad-spectrum antimicrobial activity.
  • Ciprofloxacin, a prominent fluoroquinolone, is available for oral, parenteral, and ophthalmic administration.
  • These agents are utilized for treating a wide range of community- and hospital-acquired infections.

Conclusions:

  • Fluoroquinolones are versatile antimicrobial agents with established roles in treating diverse infections.
  • The review highlights the evolution and expanding clinical utility of this important drug class.

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