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Related Experiment Video

Updated: Jun 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

[Paraneoplastic neurological syndromes].

Anette Storstein¹, Christian A Vedeler

¹astt@helse-bergen.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke

|March 14, 2009

Summary

Paraneoplastic neurological syndromes (PNS) are autoimmune disorders affecting cancer patients. Early diagnosis and treatment of the primary tumor, alongside immunosuppression, are key for managing these rare but severe conditions.

Area of Science:

Neurology
Oncology
Immunology

Context:

Paraneoplastic neurological syndromes (PNS) are a diverse group of disorders characterized by severe neurological symptoms.
Recent advancements have identified novel antigenic targets and expanded the clinical spectrum of PNS.
PNS affect less than 1% of cancer patients, highlighting their rarity but significant impact.

Purpose:

To review the current understanding of paraneoplastic neurological syndromes.
To discuss the autoimmune etiology, diagnostic markers, and therapeutic strategies for PNS.

Summary:

PNS result from immune responses targeting antigens shared by tumor cells and neural tissues.
Onconeural antibodies in serum and cerebrospinal fluid are crucial diagnostic markers for PNS.

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Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

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Last Updated: Jun 24, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

Published on: August 25, 2023

Treatment involves addressing the underlying malignancy and employing immunosuppressive therapies.

Impact:

Improved diagnostic capabilities through antibody detection.
Enhanced therapeutic approaches combining tumor treatment and immunosuppression.
Greater awareness and understanding of these complex neuro-oncological disorders.