Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Some comments on coordinate-free and scale-invariant methods in morphometrics.

S Lele1

  • 1Department of Biostatistics, The Johms Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205.

American Journal of Physical Anthropology
|August 1, 1991
PubMed
Summary

This study reveals critical flaws in the common superimposition method for comparing biological shapes. An alternative Euclidean Distance Matrix approach is proposed for 2D and 3D shape analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Docetaxel and nab-paclitaxel are safe alternative options for patients with gynecologic malignancies following hypersensitivity reaction to paclitaxel.

European journal of gynaecological oncology·2018
Same author

Use of hematologic biomarkers during chemotherapy predicts survival in ovarian cancer patients.

European journal of gynaecological oncology·2018
Same author

The CD47 "don't eat me signal" is highly expressed in human ovarian cancer.

Gynecologic oncology·2016
Same author

Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study.

British journal of cancer·2014
Same author

Evaluation of the outcome benefit conferred by intensive surveillance strategies in women with early-stage endometrial cancer.

European journal of gynaecological oncology·2014
Same author

Adjuvant treatment for uterine leiomyosarcoma.

European journal of gynaecological oncology·2014

Area of Science:

  • Morphometrics
  • Geometric Morphometrics
  • Biological Shape Analysis

Background:

  • Superimposition is a common method for comparing biological shapes.
  • This method involves aligning shapes and analyzing residual differences.
  • However, this approach has subtle but significant limitations.

Purpose of the Study:

  • To critically evaluate the superimposition strategy for biological shape comparison.
  • To identify inherent pitfalls in the superimposition method.
  • To present an alternative, robust method for shape analysis.

Main Methods:

  • Detailed examination of the superimposition technique and its associated challenges.
  • Development and application of the Euclidean Distance Matrix (EDM) representation.

Related Experiment Videos

  • Testing the EDM approach on both two-dimensional and three-dimensional objects.
  • Main Results:

    • The superimposition method contains subtle but important inherent pitfalls.
    • The Euclidean Distance Matrix representation offers a viable alternative.
    • The EDM method is applicable to both 2D and 3D biological shapes.

    Conclusions:

    • The conventional superimposition method for shape analysis has critical limitations.
    • The Euclidean Distance Matrix representation provides a more reliable approach for comparing biological forms.
    • This new method enhances the analysis of shape variation in 2D and 3D datasets.