Epithelial ion transport in the fetal and perinatal lung

The lung is a complex organ whose intrauterine development depends on many factors, one of which is a continuous secretion of large volumes of Cl(-)-enriched fluid by the pulmonary epithelium. At birth this fluid must be cleared, and it is now known that this process depends in large part on active Na+ transport by the pulmonary epithelium. Only recently has it been possible to culture some of the different lung epithelial cells so that it is possible to investigate the role of individual epithelial cell types, their individual cellular transport mechanisms, and how these are affected by developmental lung maturity.