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Cephalic phase insulin release in normal weight males: verification and reliability
K L Teff1, R D Mattes, K Engelman
1Monell Chemical Senses Center, Hospital of the University of Pennsylvania, Philadelphia 19104.
The American Journal of Physiology
|October 1, 1991
Summary
Cephalic phase insulin release (CPIR) is a reliable physiological response in normal weight males. This study confirmed its reproducibility and consistency across multiple trials, indicating a robust insulin secretion mechanism.
Area of Science:
- Endocrinology
- Human Physiology
Background:
- Cephalic phase insulin release (CPIR) is a cephalic-phase response to food.
- The reliability and reproducibility of CPIR have been subjects of investigation.
Purpose of the Study:
- To determine the existence and reliability of CPIR in normal weight males.
- To assess the reproducibility of CPIR across multiple trials.
Main Methods:
- Twenty normal weight males participated in the study.
- Each subject underwent three trials with the same food stimulus over five days.
- Blood samples were collected at 5-minute intervals pre-ingestion and every 2 minutes for 16 minutes post-ingestion.
Main Results:
- Significant increases in plasma insulin were observed at 4 minutes post-ingestion on all trial days.
- CPIR demonstrated high reproducibility between trials (r = 0.83; P < 0.001).
- A significant decline in plasma glucose was noted at 4 minutes post-ingestion on trials 2 and 3.
Conclusions:
- This study confirms a reliable cephalic phase insulin release in normal weight males.
- CPIR is a reproducible physiological response to food stimuli in this population.
- The findings support the role of CPIR in glucose homeostasis.