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Updated: Jun 24, 2026
Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
Published on: June 10, 2013
Amitriptyline treatment under chronic stress conditions: effect on circulating catecholamines and anxiety in early
Evelin M Cotella1, Ivan Mestres Lascano, Gloria M Levin
1Catedra de Fisiologia Animal, Facultad de Ciencias Exactas, Fisicas y Naturales, Universidad Nacional de Cordoba, Cordoba, Argentina.
Abstract:
The aim of this work was to determine the effect of amitriptyline (AMI) on peripheral outcomes such as plasma epinephrine (E) and norepinephrine (NE) concentration and anxiety-like behavior displayed in the plus maze test in adult male Wistar rats under variable chronic stress and daily oral administration of AMI (5 mg/kg). Animals were previously isolated from the mother for 4.5 hr every day for the first 3 weeks of life. Administration of the antidepressant AMI reduced anxiety-like behavior in animals submitted only to chronic stress but not in early maternally separated (MS) subjects or in animals subjected to the two types of stresses.
