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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
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Published on: September 26, 2013

Human Th17 cells: are they different from murine Th17 cells?

Francesco Annunziato1, Lorenzo Cosmi, Francesco Liotta

  • 1Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy.

European Journal of Immunology
|March 14, 2009
PubMed

Type 17 Th (Th17) cells have been identified as a distinct population of CD4(+) effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-gamma and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.

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