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Related Experiment Video

Updated: Jun 24, 2026

In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

In Vitro Differentiation of Naive CD4⁺ T Cells into Pathogenic Th17 Cells in Mouse

Published on: October 25, 2024

IL-17-producing gammadelta T cells.

Rebecca L O'Brien¹, Christina L Roark, Willi K Born

¹Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA. obrienr@njhealth.org

European Journal of Immunology

|March 14, 2009

Summary

This summary is machine-generated.

Interleukin-17 (IL-17) is produced by various immune cells, including T cells and macrophages. Gammadelta T cells are surprisingly significant producers of IL-17, especially in early disease stages.

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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

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Published on: April 16, 2015

Area of Science:

Immunology
Cellular Biology
Inflammation Research

Background:

Interleukin-17 (IL-17) is a cytokine crucial for host defense and inflammatory responses.
IL-17 production is traditionally associated with CD4(+) alphabeta T cells.
The role of IL-17 in various diseases, particularly those involving neutrophil recruitment, is well-established.

Purpose of the Study:

To investigate the diverse cellular sources of IL-17 beyond conventional T cells.
To highlight the specific contribution of gammadelta T cells to IL-17 production in disease models.

Main Methods:

Analysis of IL-17 production from various immune cell populations including T cells (alphabeta and gammadelta), NKT cells, macrophages, and neutrophils.
Utilizing multiple disease models to assess IL-17 dynamics.

Main Results:

IL-17 is produced by a broader range of cells than previously thought, including CD8(+) alphabeta T cells, NKT cells, gammadelta T cells, macrophages, and neutrophils.
Gammadelta T cells emerge as a surprisingly major source of IL-17, particularly during the early phases of several disease models.
IL-17's function in deploying neutrophils to inflammatory sites is confirmed.

Conclusions:

The cellular landscape of IL-17 production is more complex, involving multiple T cell subsets and innate immune cells.
Gammadelta T cells play a pivotal, often underestimated, role in driving IL-17-mediated inflammation.
Understanding these diverse IL-17 sources is critical for developing targeted immunotherapies for inflammatory diseases.