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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

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IL-17-producing gammadelta T cells

Rebecca L O'Brien1, Christina L Roark, Willi K Born

  • 1Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA. obrienr@njhealth.org

European Journal of Immunology
|March 14, 2009
PubMed

IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.

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