Related Experiment Video
Updated: Jun 24, 2026
07:46
In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
Published on: October 25, 2024
Diseases that may benefit from manipulating the Th17 pathway
1Department of Immunology and Rheumatology, Immunogenomics and inflammation Unit, University of Lyon, Lyon Cedex, France.
European Journal of Immunology
|March 14, 2009
Summary
The discovery of Interleukin-17 (IL-17) and Th17 cells aids disease classification. Targeting Th17 is clear for inflammatory diseases but less obvious in other conditions where IL-17
Area of Science:
- Immunology
- Pathophysiology
- Disease Classification
Background:
- Interleukin-17 (IL-17) and the T helper 17 (Th17) pathway are crucial in human disease.
- Th17-mediated inflammation is implicated in various autoimmune and inflammatory conditions.
Purpose of the Study:
- To examine the role of IL-17 and Th17 in disease pathogenesis.
- To evaluate the therapeutic potential of targeting the Th17 pathway across different disease contexts.
Main Methods:
- Review of existing literature on IL-17 and Th17 in human diseases.
- Analysis of disease mechanisms involving Th17 activation.
Main Results:
- Th17 targeting is effective in diseases like rheumatoid arthritis, psoriasis, and Crohn's disease.
- The role of IL-17 in other conditions remains unclear, questioning the primary or secondary nature of Th17 activation.
Conclusions:
- IL-17 and Th17 pathways are key players in specific inflammatory diseases.
- Further research is needed to clarify the role of IL-17 in diverse conditions before widespread Th17 inhibitor application.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:28Inflammatory Response
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.