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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse

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Novel therapeutic targets along the Th17 pathway

Wenjun Ouyang1, Ellen Filvaroff, Yan Hu

  • 1Department of Immunology, Genentech, South San Francisco, CA 94080, USA. ouyang@gene.com

European Journal of Immunology
|March 14, 2009
PubMed
Summary

The discovery of interleukin-17 (IL-17)-producing CD4(+) T helper (Th17) cells has updated the Th1/Th2 model. These cells are implicated in autoimmune diseases, offering new therapeutic targets.

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