Related Experiment Video
Updated: Jun 24, 2026

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
Published on: November 6, 2019
Beyond spaghetti and meatballs: skin diseases associated with the Malassezia yeasts
1Division of Dermatology, University of Massachusetts Medical School, Worcester, MA, USA.
Abstract:
Malassezia are common lipid-dependent fungi that grow on the sebaceous areas of human skin, including the face, scalp, and upper trunk. Although Malassezia are a part of the normal human skin flora, they may also cause or exacerbate several skin diseases, including tinea versicolor, Pityrosporum folliculitis, and seborrheic dermatitis. Topical antifungals are the mainstay of treating Malassezia-related diseases. Chronic prophylaxis is often required to prevent recurrences.
Insights
Malassezia fungi are common on skin but can cause or worsen conditions like seborrheic dermatitis. Topical antifungals are key treatments, often needing long-term use for prevention.
Area of Science:
- Dermatology and Mycology: Focuses on skin health and fungal infections.
Background:
- Malassezia are lipid-dependent fungi prevalent on human skin's sebaceous areas.
- These fungi are part of normal skin flora but can cause or worsen skin diseases.
Purpose of the Study:
- To review the role of Malassezia in common skin conditions.
- To discuss current treatment strategies for Malassezia-related dermatoses.
Main Methods:
- Literature review of Malassezia-associated skin diseases.
- Analysis of current therapeutic approaches, including topical antifungals.
Main Results:
- Malassezia contribute to tinea versicolor, Pityrosporum folliculitis, and seborrheic dermatitis.
- Topical antifungals are the primary treatment modality.
Conclusions:
- Effective management of Malassezia-related skin conditions relies on topical antifungals.
- Chronic prophylactic treatment is frequently necessary to prevent disease recurrence.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Phylum Microsporidia
The Skin Microbiota
Staphylococcal Skin Infections
Candidiasis
Fungal Phylum Ascomycota
