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Zebra II as A Novel System to Record Electrophysiological Signals in Zebrafish
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Published on: August 16, 2024

Acetazolamide influences ocular pulse amplitude.

Martin S Zinkernagel1, Andreas Ebneter

  • 1Department of Ophthalmology, Kantonsspital St. Gallen, Switzerland. m.zinkernagel@gmail.com

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
|March 17, 2009
PubMed
Summary

Oral acetazolamide significantly reduces ocular pulse amplitude (OPA) and intraocular pressure (IOP). This effect, observed in glaucoma patients and healthy individuals, impacts choroidal blood flow and requires consideration during OPA measurements.

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Area of Science:

  • Ophthalmology
  • Pharmacology
  • Physiology

Background:

  • Glaucoma management often involves monitoring intraocular pressure (IOP).
  • Ocular pulse amplitude (OPA) reflects pulsatile ocular blood flow, a factor potentially influencing IOP.
  • Systemic medications can affect ocular hemodynamics.

Purpose of the Study:

  • To evaluate the impact of systemic acetazolamide on Ocular Pulse Amplitude (OPA).
  • To assess the effect of acetazolamide on intraocular pressure (IOP).
  • To determine the relationship between changes in OPA and IOP following acetazolamide administration.

Main Methods:

  • OPA, IOP, mean arterial blood pressure, and heart rate were measured in 17 patients with hypertensive primary open-angle glaucoma (htPOAG) and 22 healthy controls.
  • Measurements were recorded before and 2 hours after oral administration of 500 mg acetazolamide.
  • Statistical analysis included correlation to assess the relationship between OPA and IOP changes.

Main Results:

  • Oral acetazolamide led to a 20.24% decrease in mean OPA.
  • Intraocular pressure (IOP) decreased by 17.19% (2.98 mmHg).
  • A significant correlation was found between the reduction in IOP and the reduction in OPA (r(2) = 0.4, P < 0.0001).

Conclusions:

  • Systemic acetazolamide administration influences ocular pulse amplitude measurements.
  • A decrease in the pulsatile component of choroidal blood flow and IOP was observed in both htPOAG patients and healthy controls.
  • These findings necessitate accounting for acetazolamide's effects when measuring OPA using dynamic contour tonometry.