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Related Experiment Videos

Regularly scheduled voluntary exercise synchronizes the mouse circadian clock.

D M Edgar1, W C Dement

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305.

The American Journal of Physiology
|October 1, 1991
PubMed
Summary

Circadian rhythms can be synchronized by scheduled exercise, not just environmental cues. This study shows that the timing of spontaneous physical activity influences the biological clock, impacting sleep-wake and drinking patterns.

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Area of Science:

  • Chronobiology
  • Animal Behavior
  • Physiology

Background:

  • Circadian rhythm entrainment traditionally relies on external environmental cues.
  • Emerging evidence suggests physical activity can phase shift circadian clocks.
  • The impact of spontaneous exercise on circadian rhythm synchronization was previously unknown.

Purpose of the Study:

  • To investigate if spontaneous physical activity provides sufficient feedback to phase shift or synchronize circadian rhythms.
  • To determine if volitional exercise can entrain circadian rhythms in mice.
  • To explore the relationship between exercise timing and circadian entrainment.

Main Methods:

  • Monitoring sleep-wake, drinking, and wheel-running rhythms in mice (Mus musculus).
  • Implementing scheduled, restricted access to running wheels (12- or 6-h intervals).

Related Experiment Videos

  • Analyzing entrainment to scheduled exercise based on spontaneous wheel running.

    • Main Results:

    • 11 out of 15 mice showed entrainment of circadian rhythms to scheduled exercise.
    • Entrainment was successful when exercise began in the subjective night.
    • The timing of exercise correlated with the pre-entrainment free-running period.

    Conclusions:

    • The circadian timekeeping system responds to temporal feedback from volitional exercise.
    • Spontaneous physical activity provides physiological feedback that influences circadian rhythms.
    • The biological clock is influenced by both environmental cues and organism's own activity patterns.