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Published on: February 28, 2021
Review article: pain and chronic pancreatitis
1Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL, USA.
Alimentary Pharmacology & Therapeutics
|March 17, 2009
Summary
Chronic pancreatitis pain is challenging to manage, often requiring advanced treatments beyond conservative options. Future therapies aim to improve pain relief for patients with this condition.
Area of Science:
- Gastroenterology
- Pain Management
- Pancreatology
Background:
- Chronic pancreatitis presents significant pain challenges for patients and clinicians.
- Pain is the most frequent and impactful symptom, often refractory to conservative treatments.
- Many patients require opioid analgesics or invasive endoscopic/surgical interventions.
Purpose of the Study:
- To review the pathophysiology and management strategies for chronic pancreatitis pain.
- To emphasize recent advancements and future directions in pain management.
- To provide an expert overview of current and emerging treatment options.
Main Methods:
- Comprehensive literature search of PubMed using keywords: chronic pancreatitis, pain, treatment, management.
- Manual search of recent conference abstracts for relevant studies.
- Expert review of identified literature.
Main Results:
- Pancreatic pain exhibits heterogeneous pathophysiology and manifestations.
- First-line treatments include lifestyle changes, enzyme therapy, and adjunctive agents.
- Refractory pain may necessitate potent opioids, neurolysis, or surgical interventions, requiring specialized expertise.
Conclusions:
- Chronic pancreatitis pain management remains complex.
- A stepwise approach, starting with conservative therapies, is recommended.
- Novel therapeutic strategies are on the horizon to improve patient outcomes.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include: