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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

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Related Experiment Video

Updated: Jun 24, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.

Nobuyo Narita1, Yasuhiro Kobayashi, Hiroaki Nakamura

  • 1Department of Orthopedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Nagano, Japan.

Nano Letters
|March 17, 2009
PubMed
Summary

Multi-walled carbon nanotubes (MWCNTs) show promise as bone biomaterials. These carbon nanomaterials were found to inhibit bone resorption and osteoclast differentiation, suggesting beneficial effects for bone health.

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Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
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Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jun 24, 2026

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
11:52

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Published on: January 27, 2023

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells
10:52

Differentiation and Characterization of Osteoclasts from Human Induced Pluripotent Stem Cells

Published on: March 22, 2024

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Bone Biology

Background:

  • Multi-walled carbon nanotubes (MWCNTs) are increasingly explored as biomaterials for bone applications.
  • Understanding cellular responses to MWCNTs is crucial for their safe and effective use.

Purpose of the Study:

  • To investigate the effects of MWCNTs on bone cells, specifically osteoclasts.
  • To determine if MWCNTs influence bone resorption and osteoclast differentiation.

Main Methods:

  • In vivo studies assessing MWCNT impact on bone resorption.
  • In vitro experiments evaluating MWCNT effects on osteoclast differentiation and key transcription factors.

Main Results:

  • MWCNTs significantly inhibited osteoclastic bone resorption in vivo.
  • MWCNTs suppressed osteoclast differentiation in vitro.
  • A key transcription factor for osteoclastogenesis was suppressed by MWCNTs.

Conclusions:

  • MWCNTs demonstrate inhibitory effects on bone-resorbing cells (osteoclasts).
  • These findings suggest potential beneficial roles for MWCNTs in bone biomaterial applications.