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Related Concept Videos

Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the appropriate...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.

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Related Experiment Video

Updated: Jun 24, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

A blueprint for pharmacy benefit managers to increase value.

William H Shrank1, Michael E Porter, Sachin H Jain

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA. wshrank@partners.org

The American Journal of Managed Care
|March 17, 2009
PubMed
Summary

Pharmacy benefit managers (PBMs) can improve healthcare value by focusing on cost-effective drugs, timely therapy initiation, and patient adherence. Evaluating PBMs on health outcomes, not just cost control, drives innovation and better results.

Related Experiment Videos

Last Updated: Jun 24, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Area of Science:

  • Health economics
  • Pharmaceutical policy
  • Healthcare management

Background:

  • Pharmacy benefit managers (PBMs) are key players in the healthcare system.
  • Current evaluation of PBMs primarily focuses on cost containment.
  • There is a missed opportunity to leverage PBMs for health improvement.

Purpose of the Study:

  • To propose a new framework for evaluating PBMs.
  • To identify key dimensions for PBMs to generate healthcare value.
  • To advocate for a shift in PBM evaluation from cost control to health outcomes.

Main Methods:

  • Conceptual analysis of PBM roles and impact.
  • Identification of three core dimensions for value creation by PBMs.
  • Discussion of requirements for implementing a value-based PBM model.

Main Results:

  • PBMs can create value through three primary dimensions: cost-effective medication use, timely initiation of appropriate therapy, and adherence to prescribed treatments.
  • Achieving this value requires integrated data systems, enhanced patient and physician partnerships, and robust measurement and reporting.

Conclusions:

  • Re-evaluating PBMs based on health outcomes and value generation is crucial.
  • Incentivizing PBMs to promote value will foster innovation and improve patient health.
  • A shift towards value-based evaluation can transform the healthcare system.