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Updated: Jun 24, 2026

Utilizing Thermal Shift Assay to Probe Substrate Binding to Selenoprotein O
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Utilizing Thermal Shift Assay to Probe Substrate Binding to Selenoprotein O

Published on: August 9, 2024

Selenoprotein function and muscle disease.

Alain Lescure1, Mathieu Rederstorff, Alain Krol

  • 1Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC F-67084 Strasbourg, France. a.lescure@ibmc.u-strasbg.fr

Biochimica Et Biophysica Acta
|March 17, 2009
PubMed
Summary
This summary is machine-generated.

Selenium

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Methods to Assess Subcellular Compartments of Muscle in C. elegans
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Published on: November 13, 2014

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Muscle Physiology

Background:

  • The essential trace element selenium is vital for human and livestock health, particularly for striated muscle function.
  • Molecular mechanisms of selenium's role in muscle remain largely unknown.
  • Recent identification of selenoproteins aids in understanding these processes.

Purpose of the Study:

  • To investigate the roles of selenoprotein W (SelW) and selenoprotein N (SelN) in muscle development and maintenance.
  • To characterize the functional consequences of mutations in the SEPN1 gene, which cause SEPN1-related myopathy.
  • To explore the involvement of SelN in oxidative stress and calcium homeostasis.

Main Methods:

  • Characterization of cellular and animal models.
  • Analysis of SEPN1 gene mutations.
  • Investigation of selenoprotein functions in muscle.

Main Results:

  • Mutations in the SEPN1 gene lead to SEPN1-related myopathy, a group of neuromuscular disorders.
  • Selenoprotein N (SelN) appears to play a significant role in regulating oxidative stress and calcium homeostasis.
  • SelN's function is crucial for muscle maintenance.

Conclusions:

  • Selenoprotein N is critical for muscle health and function.
  • Understanding SelN's role in oxidative stress and calcium regulation opens new therapeutic avenues for neuromuscular disorders.
  • Further research into selenoproteins can advance the development of treatments for muscle-related diseases.